Sentence examples for lead to mediated from inspiring English sources

Activation and localization of PAK1 lead to mediated physiological effects of downstream signaling via activating additional kinases and other effectors by phosphorylating them at specific serine and threonine residues or through protein protein interaction.

However, the FBN1 mutation in that family lead to nonsense mediated decay of the mutant transcript, not being able to exert a dominant-negative effect.

In the present study, we have delineated an alternative orchestra of signaling events that would also lead to IL1B mediated attenuation of gastrin expression.

PF4 has been most studied in the context of heparin induced thrombocytopenia during which PF4-heparin complexes are immunogenic and lead to antibody mediated platelet destruction [37] [39].

Does apelin mutation lead to nonsense mediated degradation of apelin mRNA?

Consequently, in diabetic patients systemic hyperosmolality might lead to NFAT5 mediated release of proinflammatory cytokines.

These include five transcripts containing PTBP2-dependent exons with mapped CLIP clusters whose change in splicing is predicted to lead to nonsense mediated decay.

The CDH1 1054 del83 isoform was suggested to move the reading frame and create a PTC with 358 aminos, which would presumably lead to nonsense mediated mRNA decay.

This provides further evidence that radiation and immunotherapy can lead to immune mediated cell kill in patients with established tumors who have already undergone other cancer treatment modalities.

Alternatively, irradiated solutions of PEGMA and TGFβ1 may lead to radical mediated damage through chain transfer, and the solutions can be subsequently assayed for protein concentration or bioactivity.

In vitro studies suggested that severe iron restriction could lead to p53-mediated neuronal apoptosis.