These events lead to marked reduction in T-cell proliferation and secretion of pro-inflammatory cytokines.
In vivo, SLC6A4 variants in humans and other species lead to marked physiological changes, despite mitigating neurodevelopmental adaptations in 5-HT receptors plus compensatory alterations in 5-HT synthesis and metabolism.
Pre-treatment with high dose steroids or a transplantation after the second or higher relapse lead to marked cellular immunosuppression and thus to an increased risk for viral reactivations.
One mechanism that has been proposed to explain the schedule-dependent anticancer activity of temozolomide, as well as the encouraging, although preliminary, results noted with protracted low-dose schedules, is that frequent temozolomide treatment, particularly on protracted schedules, may lead to marked, cumulative, and sustained inactivation of O-alkylguanine-DNA alkyltransferase (AGAT).
Also recently it was shown [ 29] that loss of polarity of RPE cells in AMD may results in alteration of PEDF, VEGF expression and lead to marked loss of neurotrophic and vascular support for the retina potentially leading to photoreceptor loss and blindness.
Upper limb fracture is a common musculoskeletal injury and can lead to marked pain-related disability.
Changes in host population sizes can lead to marked shifts in community composition and ecosystem functioning3,4,6.
Even within a community, cultural factors – such as an eldest son preference in South Asia – can lead to marked differences in height outcomes.
This surprising result led the scientists to propose that even simple computer games like Tetris can lead to "marked increases in the speed of information processing".
The simulation study shows that different feed configurations lead to marked differences on the partial pressure profiles of the different species across the membrane, and explains the performance order (in terms of the selectivity conversion behaviour) that was observed experimentally.
Although molecular-level experiments have enabled sampling of individual ligand-receptor complex dissociation events, disparities in measured unbinding force FR among these methods lead to marked variation in inferred binding energetics and kinetics at equilibrium.
