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However, delayed payments have placed PPS under threat of collapse, which could lead to major challenges in procuring affordable ARVs when donor funds are no longer available.
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This has led to major challenges right across the industry, from the likes of Zynga's Wall Street woes, and Zattikka's financial problems, to a refocus on quality and "differentiation" by Europe's Bigpoint.
This leads to major challenges for people, especially for families with small children in deciding on how to address the risks they are exposed to.
Roberta Kaplan, the lawyer who successfully argued the Doma case, said "there is nothing" in Friday's ruling that she was concerned about that could lead to major legal challenges.
Maybe this enthusiastic advocacy will someday lead to major reforms.
This can lead to major problems.
This can lead to major problems though!
Jeronimo is used to major challenges.
This leads to a major challenge to design the turbine housing in order to ensure its guaranteed lifetime in relation to the high temperature behaviour of the material.
We challenge readers to provide an example of open clinical trial data sharing that has led to major public health harm.
This has led to major goal displacement.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com