Sentence examples for lead to major alterations from inspiring English sources

Ascomycota are able to grow in media supplemented with high concentrations of an ionic liquid, which, in turn, lead to major alterations in the fungal metabolic footprint.

The focus group and cognitive interviews didn't lead to major alterations in the Dutch translation of the PAM 13, though some items were slightly rephrased.

Thus, we believe it is of particular importance to monitor cultured cell lines very closely as small changes to a cell type can lead to major alterations of expression patterns for some non-coding RNAs.

Our results suggest that changes in the hydrophobic regions do not lead to major alterations to the structure and function of the elastin protein, as long as the overall hydrophobic properties are maintained.

Exposure to high concentrations of CsA (15 μM) led to major alterations of the biodistribution of CsA over time.

In mice, disruption of growth hormone (GH) signaling that leads to major alterations in IIS has a well-documented positive impact on lifespan [ 4].

This leads to major alterations of mitochondrial membranes morphology and curvature, with the appearance of collapsed cristae packaged in multiple concentric layers (Acehan et al., 2007).

Overall, we find that lasting overexpression of PGC-1α leads to major alterations in the metabolic activity of neuronal cells which dramatically impair dopaminergic function in vivo.

Our study indicates that plectin deficiency in skeletal muscle fibers leads to major alterations of various mitochondrial aspects, including changes in shape and network organization, deficits in respiratory functions and reduced overall content.

In addition, this major meningeal inflammation can lead to major vascular alterations of the meningeal vessels, as occurs in vasculitis, facilitating microthromboses and participating in profound alterations in cerebral blood flow and anoxia [ 17].

Consequently, removal of all heptad-repeats lead to major structural alterations and corresponding loss of enzymatic activity [59], [60].