Sentence examples for lead to irreversible effects from inspiring English sources

They worry that tampering with the gut microbiome could lead to irreversible effects".

In conclusion, the proposed model assumes that (a) sensory irritation occurs at lower concentrations than tissue irritation, (b) sustained exposure or high concentrations trigger a pathway-dependent response cascade, (c) certain steps lead to irreversible effects on both pathways, and (d) the two pathways become indistinguishable when morphologically and biochemically ascertainable changes occur.

A cocktail of molecular mechanisms (direct and indirect) is thus certainly used by parasites to interfere with the normal functioning of the host's central nervous system (Lefèvre et al. 2009; Libersat et al. 2009), which could lead to irreversible effects on host behavior.

It is perplexing that editors of international toxicology journals seem to be unaware of the fact that endocrine systems also have a programming role during development, and that disruption of these programming events leads to irreversible effects that go far beyond disturbances of homeostasis [ 1].

This article focuses on frictional effects, which lead to irreversible degradation of mechanical energy into internal energy through viscous dissipation.

Noradrenaline and adrenaline, particularly at high doses, have potent vasoconstrictive effects that can lead to irreversible tissue ischemia [ 2, 26, 27].

The effects of chronic axotomy on muscles lead to irreversible fibrosis and changes that prevent successful reinnervation.

In contrast to the repressor/transactivator-dependent systems, the effects of the Cre-lox system lead to irreversible changes in the vector genome.

This persisting microvascular dysfunction may be caused by cumulative effects of inflammation, which in the long run lead to irreversible vascular damage.

Inflammatory dysregulation affects multiple organs through effects on endothelial, epithelial and immune cells, which can lead to irreversible damage and death of the host.

Repetitive acute effects of cigarette smoke exposure may accumulate and after many years lead to irreversible lung damage.