Sentence examples for lead to increased efficacy from inspiring English sources

Alternate and sustained drug delivery models, such as injectable agents and punctal plug delivery systems, may in the future alleviate some such concerns and lead to increased efficacy of treatment while minimizing adverse effects.

The performance of the classifier, which achieves a PPV of >0.8 across two independent datasets, and the resulting reduction in testing cost as well as case-finding burden, suggests that application of this classifier could lead to increased efficacy of targeting these high-risk patients for enhanced evaluation and intervention.

With a higher level of cisplatin within the tumors, we predicted that this would lead to increased efficacy in tumor control.

For phase I designs, the traditional assumption that increasing dose will always lead to increasing efficacy, appropriate for cytotoxic agents, is not applicable to novel therapeutics such as in colorectal carcinoma.

Prolonged contact time and lubricating effectof gel anesthesia leads to increased efficacy and avoids the need for frequent corneal wetting.

However, it is uncertain whether targeting higher blood concentrations leads to increased efficacy of vancomycin and/or risk of nephrotoxicity in elderly patients.

This is reflected by the substantial amount of evidence in which the inhibition of one or more of the downstream protein products (e.g., HO-1, COX-2, HSP70) from these pathways has led to increased efficacy of PDT.

Drug-induced cell toxicity is considered to be in correlation with the amount of the DNA-Top cleavage complex [2] and our hypothesis was that stabilization of this complex would lead to increased drug efficacy.

Thioredoxin has also been reported to be upregulated during hypoxia (Berggren et al, 1996) and this, we hypothesise, may lead to increased AW464 efficacy under hypoxic conditions.

In cochlear implant patients fibrous tissue will lead to increased electrode impedance and consequently increased power consumption, thereby reducing the efficacy of the device.

Therefore, coadministration of dexamethasone may lead to increased metabolism of gefitinib, with consequently lower plasma concentrations and potentially reduced efficacy.