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Replacing the 1,3-diketone by a pyrazole group may lead to increased anticancer activity.
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Therefore, inhibition of autophagy may lead to increased cytotoxicity when applied in combination with anticancer drugs.
Previously, we have found that MAD2 overexpression leads to increased sensitivity to several DNA-damaging anticancer drugs, especially cisplatin, in NPC cells, which is associated with activation of the apoptosis pathway (Cheung et al, 2005).
Combination of ABT-737 with various anticancer drugs often leads to increased cell death, but these compounds often induce multiple BH3-only proteins.
Furthermore, it has been shown that ectopically overexpressed Id1 is able to suppress PARP cleavage in response to different anticancer drugs, which leads to increased apoptosis rates and increased cleaved PARP in different cancer cell lines (Zhang et al, 2007).
Recent analyses of the evolution of cancer at the population level show how rapid changes in human environments have augmented cancer risk, how strong selection has frequently led to increased cancer risk as a byproduct, and how anticancer selection has led to tumor-suppression systems, tissue designs that slow somatic evolution, constraints on morphological evolution and even senescence itself.
"Increased repression leads to increased protest".
That visit led to increased religious tolerance.
This leads to increased CHF.
Increasing lemma frequencies led to increased fluency.
Increased progranulin translation led to increased secretion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com