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Some duplications in both the type-I and type-III interferon gene families have lead to inactive pseudogenes.
For kinases, over-expression can lead to inactive protein subcomplexes (Gibson et al., 2013).
Therefore, excess sun exposure can lead to inactive photoproduct and a decrease in vitamin D status.
Heteromerization of death receptors DR4 and DR5 may also lead to inactive complexes.
The perturbation simulations in BT474 did not lead to inactive AKT upon combined pertuzumab and erlotinib treatment.
Although most of the defective structures, deriving from a wide variety of rearrangement mechanisms, lead to inactive elements, some of them remain mobile like TRIM, LARD, and BARE2 elements (Witte et al. 2001; Kalendar et al. 2004; Tanskanem et al. 2007).
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Removal of the acetic acid moiety led to inactive or weakly active target compounds.
The expression of recombinant proteins in Escherichia coli often leads to inactive aggregated proteins known as the inclusion bodies.
A decrease of pH below 0.8 led to inactive microorganisms.
All drugs, except trastuzumab under stimulation alone, led to inactive attractor states of RPS6.
Minor modifications, such as N-alkylation of the secondary amide, led to inactive analogues.
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CEO of Professional Science Editing for Scientists @ prosciediting.com