Sentence examples for lead to inactivation of from inspiring English sources

If they bind to heterodimer leading to inactivation of CDC42, then the overexpression of ROBO4 will lead to inactivation of CDC42, so in this case probability of an unknown ligand for ROBO4 remains open.

Conventional gene targeting approaches lead to inactivation of the target gene in all tissues.

Fusion of proteins can lead to inactivation of one or both parts of the fusion protein [[18]].

Both icd and acnA knockouts are known to be instable under aerobic conditions as they lead to inactivation of gltA, possibly because of a toxic effect of intracellularly accumulating citrate (Gruer et al. 1997).

Aggregation might be prevented by using a high-speed homogenizer or by sonication during CSNP preparation, but such approaches would lead to inactivation of ASNase and thus could not be used.

Thus AP2C3 ability to control activity of MPK4 may lead to inactivation of this kinase in AP2C3oe plants resulting in cytokinesis defects.

Oxidation of MKPs leads to inactivation of the phosphatases and thereby serves to sustain JNK activation.

In contrast, nonreversible, "conventional" pegylation of insulin led to inactivation of the hormone.

In contrast, phospho-deficient mutations at these sites led to inactivation of eNOS.

Inoki et al. (2003) proposed that, during glucose deprivation, AMPK-dependent phosphorylation of TSC2 leads to inactivation of the mTOR pathways and protection from apoptosis.

Par-6 PDZ regulation is required for function as mutational disruption of Cdc42-Par-6 PDZ coupling leads to inactivation of Par-6 in polarized MDCK epithelial cells.