Sentence examples for lead to important modifications from inspiring English sources

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However, 3 triple mutation lead to important modifications in SRS1, SRS6, and SRS4 and may change the substrate specificity of these enzymes.

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The variation of the fraction of the HS molecules is accompanied by the variation of other thermodynamic parameters and leads to important modifications of the magnetic, optical, and structural properties of material.

TPR, H2 chemisorption, XPS and test reaction results show that the addition of a second metal to Pt leads to important modifications of the structure of the metallic phase, though these modifications are different according to the nature of the support (Al2O3 or C).

The results of the present study showed that the transformation by A. rhizogenes strain A4 led to important modification of the metabolic pathways.

In this report we show that evaluation of the mechanisms that regulate HSF1 activity in yeast via post-translational modifications can lead to important insights into the mechanisms that regulate HSF1 in mammalian cells.

As deduced from the Rosensweig equation and under certain experimental conditions, both Néel and Brownian relaxation times are comparable for SPM nanoparticles around 10 nm; therefore, changes in the particle concentration, solvent viscosity or particle surface modification could lead to important differences in the SAR observed.

Moreover, by integrating the expression values of the three profiles into the network structure, we found that the expression modification of some nodes could lead to important alterations of the network topology.

Taken together, these results suggest that adaptation to statins led to important phenotype modifications, which, collectively, conferred a reduced ability of tumour cells to grow in immuno-compromised mice.

Replicability is subject to important modifications to the Programme strategy.

Preliminary characterization of the non-fractionated materials showed that a low difference in their average tacticity (PP2>PP1) leads to an important modification of their rigidity properties.

PMA treatment of MCF-7 cells led to an important modification of the actin cytoskeleton organization and, in consequence, of the cell morphology.

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