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While ExMV-derived mRNAs may be translated in target cells into appropriate proteins, miRNAs regulate expression of corresponding mRNA species, and both RNA-depended ExMV-mediated mechanisms lead to functional changes in the target cells.
Darwinian positive selection may lead to functional changes of the target genes during evolution.
However, modifying the genome structure will inevitably lead to functional changes.
These oxidative modifications lead to functional changes in various types of proteins (enzymatic and structural), which can have substantial physiological impact.
It is conceivable that a prolonged training of a visuomotor task might additionally lead to functional changes in brain areas outside the sensorimotor cortex.
In some respects this is the driving force of the question: whether the small changes in membrane potential brought about by STDP protocols can lead to functional changes at the spiking level.
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This is consistent with population genetic theory that duplicated genes can be retained on the long term through accumulation of mutations that lead to functional change in one or both copies [ 7].
Acidosis leads to functional changes of endothelial cells [45] that, in principle, could either hinder NCs homing or damage NCs migrated into the ischemic core region.
These improvements of motor and qEEG function suggest that PPADS treatment protects cells against the consequences of ischemia-induced release of ATP and therefore leads to functional changes possibly also reflected by alterations of the infarct size.
GUH-2 ability at acquiring foreign DNA was found significant and to have led to functional changes likely beneficial for its environmental cycle and opportunistic colonization of a human host.
More importantly, this modulation of this pathway led to functional changes in cell viability, suggesting that this pathway may be the pharmacological target in the regulation of autophagy in cardiomyocytes.
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