Sentence examples for lead to functional alterations from inspiring English sources

To evaluate the functional consequences of manipulation of ZO-1 or ZONAB expression in RPE cells, we next assessed whether the changes in the RPE morphology lead to functional alterations by fluorescein angiography.

The duplication events have led to Sry proteins that have amino acid variations that lead to functional alterations in nuclear localization and transcriptional activity.

Whether chromosomal aberrations lead to functional alterations in BM-MSCs and how this influences disease progression and outcome in leukemia patients remain to be fully elucidated.

To better understand if the variations, especially non-synonymous variations, lead to functional alterations to the corresponding genes, the SIFT algorithm [ 30] was also integrated into Exome-assistant.

Oxidative stress theory is presently the most accepted explanation for the aging which holds that increases in ROS lead to functional alterations, pathological conditions and other clinically observable signs of aging, and finally death [ 147].

These data indicate that p53 knockdown leads to functional alterations consistent with p53 deficiency.

Alternatively, the absence of spermatogonia in most seminiferous tubules of our patient might have led to functional alterations in Sertoli cells, disrupting their ability to synthesize AMH.

In opposition to ischemia, cortical lesion made by ablation does not induce significant adaptive plasticity of corticocortical and corticostriatal projections and leads to functional alterations other than those observed after ischemia.

The widely accepted oxidative stress theory of aging states that accumulation of reactive oxygen species (ROS) occurs with age and leads to functional alterations and pathological conditions (Kregel & Zhang, 2007).

They support the concept that mtDNA deletions in human skin fibroblasts lead to functional and structural alterations of the skin.

Repeated stress may lead to functional and structural alteration in the brain network.