Sentence examples for lead to extensive differences from inspiring English sources

However, already minor variances in their chemical and physicochemical properties lead to extensive differences in their biological and pharmacological effects.

Although this is the most recent ancestral state we investigate here, gene losses and acquisition of genes via horizontal transfer have led to extensive differences in genome content among descendants of this node with some E. coli strains differing by as much as 25% of their gene content [ 28].

High rates of gene exchange due to HGT can lead to extensive gene repertoire differences among otherwise closely related lineages and can result in genes within the same genome having conflicting evolutionary histories (Feil et al. 2001; Gogarten et al. 2002; Ochman et al. 2005; Shapiro et al. 2012).

The fundamental difference in growth temperature requirements and its inevitability lead to extensive investigation of the properties of InGaAs QDs annealed in situ [12 15] and ex situ [15 21].

Seasonal acclimation can lead to extensive transcriptional adjustments in teleosts [ 38- 41] and may thus account for some of the transcriptional differences observed here.

Such gradients are thought to lead to extensive local hardening.

Even postoperative complications can lead to extensive bleedings.

Ultimately, telomere deprotection can lead to extensive end-to-end telomere fusions, a catastrophic cellular event.

Infection with G. destructans can lead to extensive loss of dermal integrity.

The continuous inflammatory processes lead to extensive remodelling and destruction of the joint-architecture [ 1].

Fragility fractures lead to extensive use of health care resources and high costs of care [ 18- 23].