Sentence examples for lead to exacerbated from inspiring English sources
Poor adherence can lead to exacerbated health issues and prolonged disease severity.
This also would produce serious challenges for water resources management and likely lead to exacerbated problems for agriculture, industry, urban communities, and the environment (Qin et al., 2010b).
We showed that mAb 1A8 binds exclusively to Ly6Ghigh neutrophils in the airways of influenza virus-infected mice and specific depletion of Ly6G+ cells with mAb 1A8 lead to exacerbated disease in mice infected with virus strain HKx31 (HKx31.
Several published studies in this area have demonstrated that RA downregulates inflammatory responses in murine models of colitis [ 4, 33] and that vitamin A deficiency can lead to exacerbated experimental colitis [ 34].
Overall, we observed that rapid progression is characterized by a strong MyD88-dependent TLR activation in the absence of an effective anti-SIV specific response, causing an unbalance that can lead to exacerbated inflammatory response and lack of control over viral load.
The shelterin complex, composed of six mammalian telomere-binding proteins TRF1, TRF2, TIN2, POT1, RAP1, and TPP1, and its associated proteins protect telomeres from nucleases and DNA damage repair mechanisms that can lead to exacerbated telomere shortening or cellular senescence (Diotti and Loayza 2011).
Overexpression of Beclin 1 led to exacerbated hypertrophic growth in response to pressure overload.
Cardiac pressure overload in TIMP3-deficient mice led to exacerbated LV remodeling, and dysfunction [ 147], and to severe myocardial fibrosis [ 148].
Unexpectedly, we found that pharmacological inhibition of PDGFRβ signaling in the context of chronic aeroallergen exposure led to exacerbated lung dysfunction and airway smooth muscle thickening.
Though an association with neurodegenerative disease has not previously been established, one study showed that necdin ablation in mice led to exacerbated dopaminergic cell loss after MPTP exposure, while overexpression of an AAV-necdin construct almost completely abrogated MPTP-induced dopaminergic cell loss [ 101].
A wide range of risk drivers are now known to lead to and/or exacerbate the emergence and spread of infectious disease, including global trade and travel, the overuse of antibiotics, intensive agriculture, climate change, high population densities, and inadequate infrastructures, such as water treatment facilities.
