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Specific knowledge of chondrocyte biomechanics could lead to elucidation of disease etiologies and the biomechanical factors most critical to stimulating regenerative processes in articular cartilage.
This review will focus on experimental approaches currently under study that may lead to elucidation of effective strategies for therapy in OA, with emphasis on mediators that affect the function of chondrocytes and interactions with surrounding tissues.
Direct comparison of high resolution functional MRI results between the four groups in a large-sized cohort, may delineate functional and structural alterations and characteristics of the brain related to interictal WPH and acute CA, which would lead to elucidation of the pathophysiology of migraine.
Such markers may also lead to elucidation of the biochemical mechanisms responsible for host response and resistance to infection.
The study of these properties may lead to elucidation of mechanisms for salt tolerance.
Eventually, these new techniques for identifying regulatory elements should help to accelerate development of applications in medical sciences and lead to elucidation of the causes of different diseases.
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Such possibility exists because GADPH is a strong antigenic protein, especially during infections, which leads to elucidation of anti-GADPH AAbs [22] and similarity in the amino acid sequence of Streptococcal and human proteins explains a cross-reactive immune response against this protein [27].
The insights of Dorfman-Chanarin syndrome also led to elucidation of the synthetic pathway of acylCer (see next section).
Investigations of the Neurospora circadian clock system have led to elucidation of circadian clock regulatory mechanisms that are common to all eukaryotes.
Also, study of the CFTR interactome has led to elucidation of the molecular defect of S13F- CFTR [ 41] as relating to defective interaction with filamins, which anchor plasma membrane CFTR to the actin cytoskeleton [ 41].
It is also possible for the computer to carry out many of the logical steps in reducing the data that lead to structural elucidation.
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