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Based on this finding, we hypothesize that the comparative epigenetic analysis of the changes induced by different AML1-MTG fusion proteins in an identical cell context (e.g. the 32D context) might provide a lead to elucidating the differences observed in leukemic cells carrying either one of the two proteins [ 8].
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The LCST conformational transition predicted by simulation agreed well with experimental results, and simulation results notably leads to elucidate mechanism that torsional energy of isopropyl acryl tethers and H-bond play vital roles in driving the transition in response to temperature changes.
The combined approaches led us to elucidate the overall and individual mechanisms of the metabolic fate of the studied 4-aminopiperidine drugs, especially their N-dealkylation reactions.
It is also well documented that 50%% or more of those who self-injure endorse self-punishment, or self-directed anger, as a motivation for NSI [ 14], a pattern that has led subsequent studies to elucidate the role of self-criticism in NSI [ 12].
A follow-up of the outcome in LEAD subjects is necessary to elucidate whether serum FGF21 level might be a clinically-relevant vascular disease biomarker.
These clinical advances led to extensive efforts to elucidate human hypovolemic shock and to establish experimental models that emulate clinical shock.
Questions arising from our previous experiments led us to attempt to elucidate the apoptotic pathway involved in the killing effect induced by healthy women's sera.
The multiple interactions between YdaM, YciR and MlrA observed in this study in fact led us the way to elucidate the local mode of operation of module II.
This suggestion needs a 10-year prospective study that can lead to the enough evidences to elucidate the (i) role of the H. pylori in occurrence of gastric cancer in scientific view and (ii) beneficial effects of H. pylori eradication to prevent gastric cancer in highly prevalent regions of the world.
Future research should seek to elucidate what leads to these differences.
Thus, EphA4 inhibitors represent potential therapeutic leads and useful research tools to elucidate the role of EphA4 in physiology and disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com