Sentence examples for lead to dysfunction of from inspiring English sources
PD-1 expressed by T lymphocytes, particularly tumor-infiltrating lymphocytes (TILs), can lead to dysfunction of tumor-specific T cells to eliminate tumors (Tumeh et al., 2014).
This endogenous molecule has also bactericidal effect against a broad spectrum of bacteria, by nitrosation of cysteine and tyrosine residues, which lead to dysfunction of bacterial proteins.
In other diseases, defects in nuclear genes lead to dysfunction of mitochondrial proteins.
If this inflammation is severe enough, it can lead to dysfunction of the lungs like that seen in acute respiratory distress syndrome.
Obstruction of blood flow through the affected vessel may lead to dysfunction of part of the brain supplied by the artery.
Thus the impaired trafficking of APPL and possibly other proteins may lead to dysfunction of basic cellular physiology or architecture, which might eventually cause cell death and tissue deterioration.
These results raise the possibility that chronic exposure to low, subanesthetic concentrations of ketamine, while not affecting cell survival, could still impair neuronal morphology and thus might lead to dysfunctions of neural networks.
Unicuspid aortic valve (UAV) anatomy leads to dysfunction of the valve in young individuals.
If you try to have a bowel movement without an urge to evacuate, your muscles may contract instead of relax, which leads to dysfunction of the pelvic floor muscles.
Severe sepsis occurs when sepsis leads to dysfunction of at least one organ or system due to hypoperfusion or hypotension, while septic shock is associated with refractory arterial hypotension despite aggressive fluid resuscitation and with multiple organ dysfunction syndrome.
In congenital sensorineural deafness in Dalmatians, as in mouse mutants and white cats, the lack of melanocytes in the stria vascularis occurs in the embryo, and this lack of strial melanocytes leads to dysfunction of potassium channels, subsequent unrecordable endocochlear potentials and consequent severe deafness in the affected ear [23].
