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If differences in context are likely to lead to different recommendations or decisions, these should be flagged [ 33, 35].
Initially the two decision frameworks lead to different recommendations.
The relative importance of a stroke and serious gastrointestinal bleeding varies widely (among both physicians and patients) and these different values lead to different recommendations and decisions about whether to use anticoagulants [13].
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Interestingly, the [18F] FDG-PET data collected during these independent studies led to different recommendations in the doses of RO5126766 and RO4987655 for phase II [29].
The impact of ESAs on quality of life (QoL) is controversial and led to different recommendations of medical societies and authorities in the USA and Europe.
For the time being, the question has not led to different recommendations about testing A1C or to different interpretations of the clinical meaning of given levels of A1C in those populations.
Consequences of different evolutionary constraints in stem and loop regions of rRNA sequences for phylogenetic analyses has long been suspected and led to different recommendations for weighting stem positions in parsimony analyses [ 2, 7, 8].
For the time being, the question has not led to different recommendations about testing A1C or different interpretations of the clinical meaning of given levels of A1C in those populations.
Because the results of clinical investigations have led to different recommendations concerning stress ulcer prophylaxis, Cook et al [ 1] performed a meta-analysis of randomized trials to resolve the controversies associated with previous research in this area.
These observations on the harmful effects of ESAs in cancer patients led to different recommendations of medical societies and authorities in the USA and Europe (Information for Health Professions, 2007; Aapro and Link, 2008; Rizzo et al, 2010; Schrijvers et al, 2010).
PK modeling of available data on PDA treatment with paracetamol in different gestational age groups can lead to different dosing recommendations per age group; a trial with these dose recommendations of paracetamol for PDA is also an option for future research.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com