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Targets identified by SA are mostly isoenzymes that lead to deletion of new reactions in the shortest possible pathway leading to the production of essential biomass metabolites.
A well-studied example is ectopic (out-of-register, illegitimate) recombination associated with repeat pairs, which can lead to deletion of functionally important genes that are located between the repeats.
Although the T cells of chimeric animals responded to alloantigen, the response was similar to that of non-chimeric control animals, suggesting that these cells did not appear to lead to deletion of alloreactive T cells.
Discovery of an outlier or of an observation with excessive influence may then lead to deletion of observation(s) and refitting the model, to be followed by verification of the model's goodness of fit to the data via examination of residuals and consideration of influential observations, etc.
Among all poly(A) sites, 1,616 could lead to deletion of trans-membrane domain.
Two sgRNAs that target one chromosome can lead to deletion or inversion between sgRNA cutting sites (Fig. 3c).
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These mechanisms can lead to deletions, insertions, replacements or larger chromosomal rearrangements.
Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.
Loss of damaged nucleotides at the break site can lead to deletions, and joining of nonmatching termini forms translocations.
The models are focused on enhanced single base substitution rates, and it would be of interest to specifically model other forms of genetic instability that might lead to deletions or to chromosomal instability.
Thus, recombination events can lead to deletions or alterations in the structure of these genes and therefore altered expression [ 12].
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