The enthusiasm with which the RNAi field has explored its clinical applications has led to the identification of several deleterious responses often triggered by these molecules such as potential for off-target effects and triggering host innate immune responses, both of which can lead to damaging secondary side-effects in the patient.
Therefore, strategies modulating the inflammatory response must be a balance between promoting resolution and mitigating negative effects of chronic inflammation that can lead to damaging fibrosis without preventing the initial onset of the response [ 31].
This might lead to damaging engine knock.
Moreover, the compressor passes through the surge zone which can lead to damaging flow reversal.
Research even shows stigma can lead to damaging health care consequences.
In 1958 a radiobiology research unit was set up at Mount Vernon hospital, in Northolt, west London, and it was there that Jack did his most significant research work, investigating the fast chemical reactions that occur following exposure to radiation and that lead to its damaging effects.
Research shows that social media browsing can lead to social comparison ― the phenomenon where viewers stack their lives up against someone else's, often to damaging effect.
(The show is abridged and altered, but not to damaging effect).
But he also said that his party's own belated decision to overhaul its lineup in Torrelodones, including his own appointment, had prompted "a boomerang effect" and led to damaging internal party feuding.
There can be an "obsession with germaphobia," he said, that leads to damaging consequences.
Accumulation of lead produces damaging effects in peripheral and central nervous systems, kidneys, and blood pressure.
