Sentence examples for lead to compound from inspiring English sources

Indeed, the replacement of the 2-dimethylaminoethoxy side chain of ring D (in 1h) with N-methylpiperazine lead to compound 1j, which is equipotent on BRAF IC50 with 1h, but has improved cellular activity.

Further research in the binding site of these PAMs could lead to compounds activating only mGlu2/4 heterodimers, which could help to understand their physiological role.

This success with a small library suggested that a more thorough effort might lead to compounds with higher affinity.

For this reason we continued our efforts to further optimize potency versus HNE, hoping that this would ultimately lead to compounds with improved RNE inhibition as well.

Replacement of the amine group with pyrrolidine, azetidine, and aziridine rings did not lead to compounds with better antiviral activities 11, 12, 13.

Iterative optimization of the initial lead compound (1) led to compound (21), a selective and potent inhibitor of wild-type Axl.

Modification of the benzyl group led to compound 2b, a highly potent p38α inhibitor.

The optimization of these compounds led to compound 48 with potent affinity for TSPO and good in vitro PK profile.

Ion irradiation of interfaces causes intermixing of the adjacent regions, which leads to compound formation in certain cases.

Modification of the N-carbethoxy piperidine moiety of compound 2, an M4 muscarinic acetylcholine receptor (mAChR -preferring agonist, led to comAChR -preferringtive M4 magonistonist.

To obtain the Comprehensive Analysis Page (C) of a herb, users can search from (A) with Herbal name; Searching by Chemical name, InChIKey or CAS number of a compound leads to Compound Information page (B1).