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The part of the sentence 'lead to changes in' is correct and usable in written English.
You can use it when referring to a cause and effect situation. For example, "Exposure to extreme temperatures can lead to changes in the chemical structure of certain materials."
Exact(60)
Changing rules and processes do not always lead to changes in organisational culture.
Ultimately, the E.P.A. analysis may lead to changes in regulations.
The ensuing litigation may also lead to changes in how deals are drafted.
The study, in time, could lead to changes in how packs engage.
I hope it will lead to changes in the accord which is harmful for democracy".
Do certain foods lead to changes in your mood, energy or sleep?
"I hope Yale's action will lead to changes in the Congress".
Such learning situations can then lead to changes in motivated behaviour.
The oil boom will, or at least should, lead to changes in U.S. policy.
Past crises, Mr James argues, show that this ferment can lead to changes in political power.
Changes in the cytoskeleton can lead to changes in cell shape, movement, metabolism, and development.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com