Demand is responsive to quality of care,[ 59, 60] and poor quality will eventually lead to bypassing of low-quality facilities to higher-quality facilities, and thus also increase inequity of access[ 20] and the effect of health systems on iatrogenic poverty[ 61].
However ATM has been shown to promote senescence by activating p53 and suppression of its activity leads to bypass of senescence [ 34, 35].
Studies from our laboratory with several hundred immortalised Hupki MEF cell lines have shown that the genetic alterations in p53 that lead to senescence bypass of MEFs are typical of human tumours.
This research perspective focuses on the evidence for a functional relationship between NF-κB and senescence, and how disruption of the NF-κB pathway can lead to its bypass.
It was reported that in papillomavirus type 16 E6- and E7- expressing keratinocytes, a high expression of UBE2C was observed, which may lead to the bypass of the spindle assembly checkpoint even with the DNA injury [ 40].
A large array of conservative bishops, notably from Africa and Eastern Europe, fear that Francis' openness and pastoral outreach towards those out of the Catholic Church may lead him to bypass its doctrine.
This method leaves little or no oil behind the driving gas, but the relatively low viscosity of the gas can lead to the bypassing of large areas of oil, especially in reservoirs that are not homogeneous.
Laboratory experiments and field pilot tests reveal that the precipitation of Mn oxide, one of the reaction products, causes a reduction of permeability, which can lead to flow bypassing and inefficiency of the scheme.
One woman described how an absence of facility-based counselling fosters distrust and leads women to bypass providers for informal pharmacies where they self-prescribe inappropriate methods: "They use medication that does not suit them.
And consumers want healthy food that won't lead to a double bypass.
