Sentence examples for lead to blockade from inspiring English sources

Pretreatment with MPP did not lead to blockade or augmentation of the inhibitory effects of ICI on PRL release.

Increased inhibition can lead to blockade of LTP induction in the hippocampus (Ji et al. 2001) and an increase in the threshold for induction of spike timing dependent plasticity (Couey et al. 2007).

Platelets, in fact, play a key role in atherogenesis, and its thrombotic complications and measures, which lead to blockade of one or multiple pathways modulating platelet activation and aggregation processes, are pivotal in reducing ischemic risk in diabetic subjects (4).

Furthermore, DIM attenuates experimental arthritis by the inhibition of the receptor activator for nuclear factor κB ligand (RANKL), which leads to blockade of osteoclastogenesis [ 126].

8 Recent studies have revealed that elevated GABA in the murine model of SSADH deficiency (aldh5a1 −/− mice) leads to blockade of mitochondrial mitophagy associated with enhanced oxidative damage.

33 Initial in vitro studies by Honiberg et al using mouse models of rheumatoid arthritis and lupus demonstrated that selective inhibition of BTK leads to blockade of B cell signaling.

1) CAP binds to HIV-1 virus particles and to the envelope glycoprotein gp120; 2) this leads to blockade of the gp120 V3 loop and other gp120 sites resulting in diminished reactivity with HIV-1 coreceptors CXCR4 and CCR5; 3) CAP binding to HIV-1 virions impairs their infectivity; 4) these findings apply to both HIV-1 IIIB, an X4 virus, and HIV-1 BaL, an R5 virus.

Blockade of angiotensin II production via ACE inhibition does not lead to complete blockade of the RAAS (Francis et al 2004).

They said that they had continued to seize territory in Ramouseh, a crucial gateway that, if taken, would lead to a blockade on government-held western Aleppo.

These results indicate that the neuromuscular effect induced by L. annulata venom resulted from damaged muscle fibers that lead to the blockade of twitches response.

Together our results strongly support the notion that PERK is required to limit acini development and that positive or negative perturbations in PERK signaling can lead to either blockade or hyper-proliferative acinar morphogenesis, respectively.