In practice, either biological factors (e.g. low gene expression) or technical ones (e.g. non-specific hybridization or fluctuations in read coverage) usually lead us to ascertain higher or lower confidence to measurements.
The original observation that YTX treatment induces fragmentation of E-cadherin in MCF-7 cells (Pierotti et al, 2003) led us to ascertain preliminarily whether similar structural alterations could be detected in components associated with E-cadherin, such as β- and γ-catenins (Ozawa et al, 1989; Mareel et al, 1997).
This pattern was quite intriguing (a nearly ubiquitous assumption with genome-wide expression arrays is that expression-level data are normally or log-normally distributed), and led us to ascertain how often such patterns occurred, and whether such were associated with diabetes-related phenotypes.
This study developed a quantitative methodology to ascertain lead indicators of student sense of community whilst undertaking a course of study.
It would be remarkable if the facilitation of 3-D shape perception occurs automatically through the neural processes that lead to COS, so to ascertain its locus, we have explored the possibility of frequency selectivity in an LGN based model.
The action of cyclin D1 in cell cycle control, its role in murine mammary gland development and oncogenesis, its altered expression in half of all human breast tumours and in the earliest stages of breast oncogenesis, as well as its apparent involvement in the action of oestrogen, have led to numerous studies to ascertain whether cyclin D1 may serve as a biological marker in breast cancer.
All patients were required to have at least 3 months of lead-in data, prior to 01/01/2007, to ascertain long term use of certain medications.
This would then lead to a detailed assessment to ascertain the underlying pathology.
Last, because in some cases it was not possible to ascertain the lead institution organizing surveillance efforts in a given country (government versus in-country research organizations or outside institutions), this information was not compiled.
In theory, all children whose parents responded "yes" or "don't know" to any of the three questions on the CDC Lead Risk Assessment Questionnaire (CDC 1997) should have been screened for lead, but it is difficult to ascertain true practice at the time.
