Sentence examples for lead to abrogation of from inspiring English sources

There is a key danger here though: critics rightly point out that this model can lead to abrogation of civil liberties (as is alleged in Ethiopia and Rwanda).

Small molecules have been developed to inhibit WEE1 on the basis that inhibition of this kinase may lead to abrogation of the G2/M checkpoint.

If the regulatory mechanisms present in yeast and mammals also are used by T. gondii, disruption of critical RPs would lead to abrogation of effect of an MDM2-like molecule, arrest in the cell cycle in G1, and hence contribute to diminution of proliferation and persistence.

These events lead to abrogation of cell cycle arrest and aberrant mitotic entry before the completion of DNA repair.

Depletion of plasmacytoid DCs (the major producers of IFN-α) does not lead to abrogation of abnormal lupus EPC/CAC differentiation in culture [ 37]; therefore, other cellular sources for this cytokine have been sought.

Mutation of the C-terminal resolving cysteine residue of CXXC motifs does not lead to abrogation of interaction, but rather in potential trapping of the substrate, more pronounced with cysteine to alanine mutations than with cysteine to serine mutation (Lee et al, 2013).

The mutations in AML led to abrogation of the E3 activity leading to prolonged RTK activation.

This was further confirmed as inhibition of NADPH oxidase led to abrogation of Tat and morphine induced toxicity and improved the viability of SHSY5Y cells.

This is supported by reports showing that over-expression of a dominant-negative mutant of PKCζ in muscle cells leads to abrogation of insulin-stimulated glucose transport and GLUT4 translocation [37], [38], while over-expression of PKCζ in skeletal muscle in vivo enhanced both basal and insulin-stimulated glucose transport [39].

Our experiments in the current study on MAPK pathways revealed the involvement of JNK and ERK1/2 pathway in Tat and morphine induced toxicity in SHSY5Y cells, since inhibition of these pathways by specific inhibitors led to abrogation of Tat and morphine mediated toxicity.

Oppenheimer has also identified that injury to adjacent right circuminsular cortex have led to abrogation of inhibition.