Thus, enhanced neuronal classical MHCI expression can lead to aberrations in neural circuitry and neurorepair.
TOAD-64 is up-regulated following neuronal induction of P19 and PC12 cells; it is re-expressed in adult spinal motor neurons following axotomy of the sciatic nerve; and is present on the lamellipodia and filopodia of growth cones.The gene encoding TOAD-64 shows sequence homology to the unc-33 gene of C. elegans, mutations in which lead to aberrations in axon outgrowth.
Neglecting these correlation effects can lead to aberrations in the structural and dynamical analysis of RDCs and diminish the utility of RDCs in probing motions between domains having similar alignment propensities.
"Recent studies reveal that a distorted circadian cycle [or changes in the body that are every 24 hours] can lead to aberrations in metabolism, producing symptoms such as obesity, insulin resistance and others consistent with the metabolic syndrome," the study said.
These gain- and loss-of-function mutations lead to aberrations in protein-protein interaction networks.
From a biological point of view this may not be favorable because gene pattern defects can lead to aberrations in development, hence development should be robust towards modest transient disturbances [ 53, 54].
An understanding at this level, however, is critical for eventual resolution of the mechanisms that underlie cell fate decisions, as well as those that lead to aberrations in cellular behavior [ 10].
Combined with the results in ovarian cancer cells, it appears that manipulation of Rab25 levels can lead to aberrations in the trafficking of β1-integrin and perhaps other critical regulators of cell adhesion.
This leads to aberration and scattering of the ultrasonic waves.
As expected, injecting embryos with MO2 (0.5–1 mM) markedly reduced viability and led to aberrations in body axis development and pericardial edema in a fashion similar to the ATG-targeted Pak1 MO1 (Fig. S3B).
