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We describe herein a proposed clinical trial designed to test: (1) the hypothesis that higher radiation doses can lead to a survival advantage in patients with non-small cell lung cancer, and (2) the value of amifostine as a cytoprotective agent in the high-radiation dose range.
4 Tailored treatment could be a major gain of neoadjuvant treatment and might ultimately lead to a survival benefit.
This may have lead to a survival bias as tuberculosis may have accounted for a substantial proportion of deaths.
Further studies investigating the mechanisms that lead to a survival advantage in cancer cells harbouring amplification and overexpression of PLEKHF1 and POP4 are warranted.
Anti-HER2 mAb, Trastuzumab, was clinically demonstrated to lead to a survival benefit in patients with HER2-overexpressing breast cancer (Slamon et al, 2001; Hall and Cameron, 2009).
In view of this, it seems premature that the paper discusses biologic mechanisms that could lead to a survival advantage for breast cancer in women with reconstructive implants.
Similar(45)
According to these findings, systematic CRT-P device optimization leads to a survival benefit and improved quality-of-life as compared to standard (non-systematic) device optimization.
Addition of anti-CD40 to debulking surgery led to a survival delay of approximately 7 days more than untreated mice.
However, combination therapy with BKM120 and PD0325901 led to a survival benefit, with median survival extended to 16 days (Fig. 5D).
Treatment at 6 days before RT led to a survival fraction at 2 Gy and a D0 value of 0.46 ± 0.05 and 2.2 Gy, respectively.
This leads to a survival rate of 86% in 1 year, which is reduced to 77% and 73% in 3 and 5 years respectively [1].
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CEO of Professional Science Editing for Scientists @ prosciediting.com