Sentence examples for lead to a subtle from inspiring English sources

69 Its inhibition can lead to a subtle lowering of blood glucose levels.

Importantly, expression of E215K triggeredgered a more pronounced increase in telomere length to ∼7.7 kb over the same time period, while E169K gave lead to a subtle increase to ∼4.9 kb.

The presence of a bulky methyl group might lead to a subtle widening of the major groove and, consequently, a subtle narrowing of the minor groove, owing to the close proximity of the methyl group to the phosphodiester backbone, which might lead to steric hindrance.

A likely explanation is that Leu20 is located in the center of the ligand binding sites and a slight change in residue size (e.g., replacement with the slightly longer residue Met) might lead to a subtle distortion in the active site, which is sufficient to decrease the rate of steady-state turnover but because of its position does not affect substrate binding.

For diseases of the mind, few environmental or genetic risk factors are understood; instead the hope is that identified genetic factors will lead to a subtler understanding of why diseases such as schizophrenia arise and how they can be treated effectively.

But the passage of time has led to a subtle and worrying development.

It also led to a subtle change in the way government did business.

This has led to a subtle downgrading of the TV broadcasters.

Her dramatic presentation of the court- martial of several mutineers leads to a subtle investigation of how the interests, and the political influence, of several families of minor gentry who wanted to save the neck of one mutineer bent the law and the rules of the British Admiralty.

For example, loss of Cdk5 led to a subtle impairment in fEPSP repolarization in the hippocampal SC/CA1 pathway.

A Dscam mutation in mice leads to a subtle defect in the caudal folium of the cerebellum [ 42].