In contrast, hypothermia in combination with haemorrhagic shock (loss of 35% of total blood volume) with subsequent haemodilution (by resuscitation with Ringer's solution) led to a prolongation of PT by 40% (assayed at 32°C), without significant effects on aPTT [36].
Nonetheless, it should be emphasized that CHF leads to a prolongation and dispersion of action potential duration that is quantitatively more pronounced in respect of pure aging.
Disturbance of this interaction leads to a prolongation of Ca2+ sparks (Uchinoumi et al, 2010), as observed in the CPVT myocytes.
Everolimus significantly reduced the risk of disease progression and led to a prolongation of PFS by 6.4 months (11 vs. 4.6 months) compared to placebo.
These data suggest the existence of the Hering-Breuer inflation/deflation reflex in adults under standard clinical conditions; this reflex, produced by increased stretch receptor activity, leads to a prolongation of expiration.
Indeed, aging typically leads to a prolongation of action potential duration due to different mechanisms, such as an increased number and overactivity of cardiac L-type Ca2+ channels with a consequent slow inactivation of calcium influx and a reduction in outward potassium current.
The changed weather conditions under the future climate projections lead to a notable prolongation of malaria transmission and an earlier start and later end of the season [ Figure 3C,D; Supplemental Material, Figures 4 6 (http://dx.doi.org/10.1289/ehp.1103681)].
However, this approach is too conservative and may lead to an unnecessary prolongation of the hospital stay.
In patients who are in the early weaning phase from mechanical ventilation, the administration of sedatives or even neuromuscular blocking agents is not desirable, because it may lead to an unnecessary prolongation of the weaning process.
The authors conclude the common practice of polytherapy with two atypical antipsychotics does not seem to lead to a significant QTc prolongation compared to monotherapy.
