Sentence examples for lead to a potent from inspiring English sources

Used as a combination, such molecules should facilitate antigen presentation by professional APCs and lead to a potent induction of T cell-mediated effector and immune memory mechanisms.

Among the first to realize that blocking bcl-2 might lead to a potent anticancer therapy was John Reed, now scientific director of the Burnham Institute in San Diego.

The further optimisation of the previously reported compounds 3 and 4 lead to a potent inhibitor with approximately a threefold improvement in activity.

Inhibition of CA9 with sulfonamide and/or coumarin inhibitors was recently shown to lead to a potent retardation for the growth of both primary tumors and metastases [ 44].

Alternatively, application of synergistic combinations of rapamycin and some agents may lead to a potent therapy for some types of solid tumours.

97 The underlying idea is elegant: blocking first the depolarizing driving force of GABA currents and Cl− accumulation using bumetanide, and thereafter increasing the GABA-induced conductance using phenobarbital or a benzodiazepine is expected to lead to a potent anticonvulsant effect.

Chronic or extended stress leads to a potent cocktail of physical changes like reduced sleep, impaired concentration, decreased ability to absorb the good stuff from the food you eat.

Extensive structure activity relationships were conducted and led to a potent FBPase inhibitor 3.9 with an IC50 of 0.99 μM.

This led to a potent, selective, and cell permeable PI3γ kinase inhibitor with good metabolic stability that was useful as a preclinical tool compound.

The initial focus on characterizing novel pyrazolo[1,5-a]pyrimidin-7(4H -one derivatives as DPP-4H -oneitors, lederivativesnt asd selective inhibitor compound b2.

Study of the structure activity relationships of compound 13 led to a potent androgen antagonist 36, which has higher affinity than flutamide (4) for androgen nuclear receptor (AR).