Sentence examples for lead to a dysfunction from inspiring English sources

"Small fluctuations from the norm can change developmental processes and lead to a dysfunction at the time of exposure, or sometimes, many years after exposure," she said.

No mutation has been found that can lead to a dysfunction of this receptor.

The aforementioned increased mitochondrial DNA mutation rate can also lead to a dysfunction of the mitochondrial respiratory chain [ 47].

Molecular genetic studies focus on mutations in the DNA-sequences, which have a negative influence on the proteins of the dopaminergic neurons and lead to a dysfunction.

It is conceivable that mutations within these genes interfere with normal cellular communications and lead to a dysfunction of the neurovascular unit, which in turn leads to impaired vasoregulation, cerebral autoregulation, and blood brain barrier permeability.

In fact, any disturbance of the cellular signalization via the P2 receptors stimulated by ADPßS at the level of the endothelium of pancreatic vascular bed as well as at the level of the cells β, can only lead to a dysfunction regarding the glycemia regulation.

It is possible that loss of the C-terminal deacetylase domain of HDAC4 leads to a dysfunction of synaptic transmission and neuronal excitability that underlie seizure.

Therefore, it is possible that the deposition of A β leads to a dysfunction of lysosomal proteolysis that would account for the accumulation of autophagic structures.

A decrease of liver blood flow leads to a dysfunction of hepatocytes and Kupffer-cells with subsequent local and systemic liberation of proinflammatory mediators [ 1] that may maintain SIRS and may lead to MODS [ 2].

This disorder underscores the fact that disruption of MRN function leads to a dysfunction of DNA DSB repair system and consequently sensitises tumour cells to DNA damage agents, including cisplatin.

On the other hand, full-field ERG measures the summed response from the entire retina, and although we have shown that ischemic vascular changes are preferentially located in the posterior pole and along the vascular arcades [ 50], the diabetic vasculopathy and neuronal damage may well lead to a generalized dysfunction of the retina.