However, we would further like to propose the possibility that the high number of existing amyloid plaques at this age and therefore the large total surface area where newly formed Aβ fibrils can attach to existing plaques could lead to a decelerated growth of each individual plaque up to a degree that it is not detectable by two-photon in vivo imaging anymore.
This may potentially be achieved by affecting the EBP1 RB-E2F transcription repression as unphosphorylated RB will inhibit the activity of the E2F family of transcription factors (Sidle et al, 1996) and will thus lead to a decelerated G1-S transition (Lee and Yang, 2003).
Further, the results showed that hypoxia led to decelerated metabolic activity, but did not lead to a significant change in the GAG/DNA ratio.
Moreover, the process of adaptation by mutation is not necessarily infinite, e.g., in bacteria diminishing returns of epistasis among beneficial mutations decelerates adaptation [ 148] and lead to an equilibrium of maximal efficiency.
The latter decelerated the increase of the glass transition temperature and led to a decrease of the E-modulus and strength in the later age.
It can be attributed to two main effects that decelerate the growth process: On the one hand, deposition leads to a depletion of platinum and copper ions in the electrolyte solution.
Furthermore, the application of a second layer of drug free CNTs on the loaded buckypaper, led to decelerate the drug release and to reduce the burst effect.
As Whitney Johnson and Juan Mendez note, "As we approach mastery, our learning rate decelerates, and while the ability to do something automatically implies competence, it also means our brains are now producing less of the feel-good neurotransmitters — the thrill ride is over". That sense of ennui eventually leads to a lack of motivation and, in some cases, poor performance.
Many techniques that assume constant velocity at the beginning of the path as derived from the trajectory determination using Ceplecha (1987) or Borovicka (1990) can lead to large errors for decelerating meteors.
Today, there are seven sources of potential global tail risk, and the global economy is moving from an anemic expansion (positive growth that accelerates) to a slowdown (positive growth that decelerates), which will lead to further reduction in the price of risky assets (equities, commodities, credit) worldwide.
Obviously, the driving habit and road conditions in a city are different from those on the highway, and slight decelerating will lead to the deviation between the estimated results and the ground truth.
