chemists/biologists at hit to lead stage.
For example, the algorithm may allow a project at the hit to lead stage to reach lead optimization in one year if fully staffed, but would correct that value to two years if only half-staffed.
Potential drug targets are then subjected to high-throughput screening for inhibitors, which often fail at the cellular level in "hit-to-lead" stages of development due to several factors [7], such as gene function redundancy [8].
cruzi agent surpassing the "hit-to-lead" stage in the drug development process.
It is at the hit-to-lead stage that academic groups both in medicinal chemistry and in biological and medical sciences can make substantial contributions, particularly with the improved biophysical technologies now available [85, 86].
They've designed a "digital mermaid bra," whose crystals sparkled in time to Azealia Banks' real-time rapping, and crafted LED stage wear for the Black Eyed Peas.
Bioisosterism and scaffold hopping are key concepts in the lead optimization stages of drug discovery [1, 2].
At rock shows, compared to the "fiery" lead on stages, many fans are dressed in boring khakis topped off with a $10 trim from Supercuts.
2.02pm: A group of 14 riders lead the stage on the descent down the Col d'Agnel.
She added: "I've carried a lead on stage, and Anne Boleyn was the closest I've come to playing a female lead on TV before.
Team Sky's Geraint Thomas retained a three-second lead after stage five of the Paris-Nice race.
