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chemists/biologists at hit to lead stage.
For example, the algorithm may allow a project at the hit to lead stage to reach lead optimization in one year if fully staffed, but would correct that value to two years if only half-staffed.
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cruzi agent surpassing the "hit-to-lead" stage in the drug development process.
It is at the hit-to-lead stage that academic groups both in medicinal chemistry and in biological and medical sciences can make substantial contributions, particularly with the improved biophysical technologies now available [85, 86].
In view of the challenges at the hit-to-lead stage previously reported in the development of mGlu4 receptor positive allosteric modulators (PAMs), a thorough structure-mGlu4 PAM activity relationship study was conducted to interrogate the chemical tractability of this chemotype.
They've designed a "digital mermaid bra," whose crystals sparkled in time to Azealia Banks' real-time rapping, and crafted LED stage wear for the Black Eyed Peas.
2.02pm: A group of 14 riders lead the stage on the descent down the Col d'Agnel.
She added: "I've carried a lead on stage, and Anne Boleyn was the closest I've come to playing a female lead on TV before.
Team Sky's Geraint Thomas retained a three-second lead after stage five of the Paris-Nice race.
Soon after regaining the lead on stage twelve, she retired with a broken oil pump.
She may not want to play the lead, vicious stage mother Mama Rose, with the nastiness required.
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