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The high lead output was a by-product of extensive silver mining which reached 200 t per annum.
However, it showed a significant association with the left ventricular lead output and with a unipolar pacing configuration.
High left ventricular lead output and unipolar pacing configuration were associated with early battery depletion, while recent-generation CRT-Ds displayed better longevity.
He was admitted with worsening heart failure and found to have intermittent PNS even with a low LV lead output (2.5 V).
Left ventricular lead output and unipolar pacing configuration were independent determinants of early depletion [hazard ratio (HR): 1.96; 95%95%% confidence interval (CI): 1.57 2.46; P < 0.001 and HR: 1.58, 95% CI: 1.25 2.01; P < 0.001, respectively].
The multivariate analysis limited to recent-generation devices, confirmed following variables as independent factors associated with battery depletion: the left ventricular lead output (HR: 3.09, 95% CI: 2.18 4.38; P < 0.001) and the Boston Scientific CRT-Ds (HR: 0.13, 95% CI: 0.04 0.40; P < 0.001).
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