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We denote with α,β,γ both the lead index and the spin channel.
Whole blood lead readings from the workers generated a cumulative blood lead index (CBLI) that approximated the level of lead exposure over time.
We then fit separate linear models to the data in each of these ranges and compared the blood lead coefficients for the concurrent blood lead index.
In this analysis, we included the XRF lead index variable to account for the paint lead in the setting of renovation.
Given the slope of 0.05 that has described the linear relationship between tibia bone lead concentration and cumulative blood lead index in subjects with chronic lead exposure in many studies (Hu et al. 2007), this increment in bone lead is roughly equivalent to a cumulative blood lead index of 580 μg/dL · years (i.e., 29 μ 0.05 = 580).
This second SNP was in moderate LD (r = 0.22) with the lead index SNP, but its addition to a joint model increased the variance explained in serum AMH from 2.7% by rs4807216 alone to 5.2% by both SNPs.
Similar(41)
We examined the relationship of the four blood lead indices with IQ (Table 4).
The relationship between blood lead indices and Full-Scale IQ was determined to be linear.
Importantly, there were no safe limits of lead indices in our study.
Although the means differed for the different blood lead indices, the results of the regression analyses were very similar.
We used mean blood lead rather than area under the curve (AUC) to maintain the same units of analysis for all four lead indices.
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