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Computational methods play an ever increasing role in lead finding.
The identification of new chemical entities that are capable of altering protein function lies at the heart of the hit and lead finding process, for which combinatorial chemistry has emerged as a powerful tool.
Starting from known drugs as a reference, such algorithms suggest drug-like molecules with motivated scaffold variations, and advanced mathematical models of structure-activity landscapes and multi-objective design techniques have created new opportunities for hit and lead finding.
Evolving compound libraries are particularly suited for hit and lead finding in situations where resources are limited and the complete testing of a large screening compound collection is prohibitive.
He scored Ohio State's first touchdown on an 18-yard run for a 7-0 lead, finding the senior wideout Brian Robiskie for a 7-yard touchdown and setting up a third unanswered score with a 56-yard pass to wideout Brian Hartline.
In our lead finding program, a series of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ones and their 5-thio-alkyl derivatives were designed and synthesized which contained different substituents at ortho-position of 2-phenyl ring attached to the fused ring structure.
Similar(39)
Told of the recent lead findings, Ms. Kempner sighed — "It's still not good enough" — and wondered if she would have to switch to something else.
Among them was racebets who takes the lead after finding that particular winner.
You're modeling and taking the lead in finding ways to connect.
That's what can lead to finding a calm amid the storminess of the technology world".
When Scott was looking for a CEO to help lead Intuit, finding someone with shared values was critical to him.
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