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Because either the loss or the gain of ohnologues may lead to dosage imbalance, ohnologues are expected to be retained intact in the genome.
However, clinical experience has demonstrated that increasing imatinib dose is related to higher rates of adverse events and may lead to dosage interruptions or cessation (Cortes et al, 2010).
(Patient) This view leads to dosage restriction for long-duration prescriptions.
Thus, the effect of H4K16 modification that ultimately leads to dosage compensation may involve levels of chromatin organization and function, which are still poorly understood.
The calculated monitor units for treatment will be less than the desired dose and lead to under-dosage due to overcorrection because the point receiving 50% of the central axis dose used for monitor unit calculation passes through the ascending portion from 50%to80%0%.
And the standards that do exist hinge on what researchers say is the crucial question in lead exposure: the dosage that a child is likely to receive over time.
A number of safety tests are performed on animals, prior to clinical trials in humans, in order to select the most suitable lead chemical and dosage form for drug development.
In real life, splitting or grinding might lead to more dosage deviation than physician's prescribing did.
We speculate that these two factors synergistically lead to protein dosage imbalance that contributes to the autistic phenotype.
Plasmid-encoded systems could also display a different dynamic behavior because of in vivo instability over time, which, when not controlled, could lead to undesired dosage effects.
Plp1tg mice with increased gene dosage lead to an increase in microglia cell number in both white and grey matter of the cerebrum when compared with B6CBA mice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com