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SNPs in the linked set that were in linkage disequilibrium (LD) were removed using the variance inflation factor method implemented in PLINK, version 1.07, (Purcell et al., 2007) to obtain an unlinked set of 79 681 SNPs.
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After LD removal, multipoint linkage analysis in the region on chromosome 3 yielded a LOD score of 2.1, whereas on chromosome 11 negative LOD scores were seen by multipoint linkage analysis after LD was removed.
Only when the fixed cost of the e-LD was removed, or substantially lowered, did e-learning devices appear to be cost-effective.
To avoid regional bias, replicates of LD-blocks were removed, so that the final set used in the analysis contains only unique LD-blocks.
Table 3 shows the results of the analyses in which (1) both SNPs rs2075650 in TOMM40 and rs769449 (which is in high LD with rs2075650) were removed, (2) rs7412 in APOE was removed, or (3) all three of these SNPs were removed from the GRS.
In this case as well, the markers that were in complete LD but located on different chromosomes were removed.
Sites that showed significant statistical association due to LD after Bonferroni correction (α = 0.05) were removed before the Structure analysis.
SNPs in the suggestively associated SNPs set found to be in LD (r > 0.9) with significant SNPs were removed from the dataset, resulting in 2,410 unique rs numbers from 412 studies.
Since very short and common ROH are often due to LD, ROH that were <500 kb long <span class="lh">were removed.
Under the first, SNPs in strong LD with other SNPs (r2 values > 0.2/0.5/0.8) were removed and the data set reanalysed.
Genes within the HLA region were removed from analysis owing to high LD and high gene density in that region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com