Only when the fixed cost of the e-LD was removed, or substantially lowered, did e-learning devices appear to be cost-effective.
SNPs were further tested for linkage disequilibrium (LD) – a SNP was removed from each pair of SNPs that had an LD (r) ≥ 0.6.
SNPs were further tested for linkage disequilibrium (LD) – a SNP was removed from each pair of SNPs that showed an LD (r) value > 0.8.
To then assess MDR's potential to detect the signal of a functional SNP through LD, the functional SNP was removed from one-locus model datasets and both SNPs were removed in turn, and then together, from the two-locus disease datasets.
When the functional SNP was removed in 80% LD and 95% LD instances, the signal sensitivities remained the same as with the susceptibility locus in place with few small exceptions.
Table 3 shows the results of the analyses in which (1) both SNPs rs2075650 in TOMM40 and rs769449 (which is in high LD with rs2075650) were removed, (2) rs7412 in APOE was removed, or (3) all three of these SNPs were removed from the GRS.
One of the SNPs was removed for each pair of SNPs demonstrating an LD of greater than 0.1 in a sliding window of 30 SNPs.
While there were many other elections taking place across the Valley that day, these three contests were 'game-changers.' In Mesa, the real strory was not that Jerry Lewis was elected to LD 18, it's that for the first time in Arizona's history, a Senate president was removed from his seat in a mid-term recall election.
To avoid regional bias, replicates of LD-blocks were removed, so that the final set used in the analysis contains only unique LD-blocks.
The order of testing required removal and immediate replacement of some of these markers when LD tape was being removed prior to analysis of the 'untaped' condition, however the same investigator did this over a very short time period.
