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The LDheatmap package (Shin et al. 2006) was used to generate plots of LD relative to genetic distance.
The nature of the DGRP in many ways minimizes the presence of LD relative to vertebrates or to line-cross-derived mapping populations.
Based on the 60 OOA individuals included in our analyses, the average inbreeding coefficient F [ Wright, 1922] was 0.026 (range of 0.0003 0.046), which is too weak to generate substantial differences in LD relative to a non-isolated population [ Hill and Robertson, 1968].
These behaviors are in sharp contrast to those of the accessions of the e3/ e4 group, which, independent of the type of allele or genotype at the E1 locus, matured without notable delays during LD relative to ND and terminated stem growth similarly under these two conditions.
LD measured as r (correlation coefficient) (Hill and Robertson 1968) for all possible pairwise comparisons on each linkage group was calculated in R (R Development Core Team 2011), and the R package LDheatmap (Shin et al. 2006) was used to generate plots of LD relative to genetic distance.
Thus, although it is true that the DGRP population has low LD relative to other eukaryotes, disequilibrium is still a major element of these data, and careful consideration should be given to its impact at all stages of an association analysis.
Similar(54)
To determine whether surface area (membrane) or volume was conserved during LD fusion, we analysed the change in volume and surface area of resulting fused LDs relative to the two donor LDs.
Applicators with the highest LDs of dicamba exposure had increased lung cancer incidence relative to low-exposed applicators but not relative to nonexposed applicators (OR = 1.6; 95% CI, 0.7 3.4) (Alavanja et al. 2004).
The dysfunctional allele at the E4 locus has adverse effects on plant morphogenesis, such as an impaired de-etiolation response under FR light [ 7] and the production of longer internodes under LD conditions relative to the E4 allele [ 43], making the plant susceptible to lodging.
Chromosome lengths and position of LD regions are relative to the length of the assembled sequence for that linkage group; most identified LD regions are <50 kb.
These plots did not reveal any notable changes in LD around knobs relative to the rest of the genome.
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