Array-based LD maps of human chromosomes contain regions with negligible apparent LD between adjacent markers, seemingly reflecting high regional recombination, which are not well defined in the maps.
The ten SNPs have good heterozygosity and are representative for LD structures of human SP4 gene in European Caucasian population according to HapMap data.
Detailed analysis of the linkage disequilibrium (LD) structure of human populations has been vital for the successful mapping of many human disease genes, understanding mechanisms underlying genetic recombination and elucidating patterns of selection and population structure [ 1].
In addition, because ancestry within an individual and patterns of LD in human populations are local within the genome, we provide quantitative assessment of model fit by considering genomic regions individually and aggregating information across the genome.
Understanding and correcting ascertainment bias is essential for a useful quantitative assessment of the landscape of LD across the human genome.
Background: Effective gene mapping based on genetic association data will require detailed knowledge of patterns of linkage disequilibrium (LD) in human populations.
The average extent of LD in the human genome has been extensively studied: it extends up to 50 kb but is highly variable, depending on the population and threshold used to measure LD [ 13, 6, 15, 16].
Theoretical predictions [ 2] as well as empirical data concerning the structure and distribution of LD in the human genome [ 3] suggest that analyses on this scale will probably be adequate for whole genome association studies targeted at common disease variants.
Rapid progress has been made in quantifying the pattern of human LD and haplotypes defined by such common variants within and among populations.
JB and LD: acquisition and isolation of human HSCs.
Densities of host-seeking I. scapularis nymphs correlate significantly with cases of human LD (3 ), but this species has been reported throughout much of eastern North America (6 – 9 ).
