While MIRA and Newbler follow the overlap-consensus-layout paradigm (OLC), CLC attempts to find paths in De Bruijn graphs.
Single molecules were assembled de novo into consensus genome maps using an implementation of the overlap-layout-consensus paradigm [ 37].
Briefly, the assembler is a custom implementation of the overlap-layout-consensus paradigm with a maximum likelihood model.
MAIA is an assembly integrator using the overlap-layout-consensus paradigm, known from genome assembly algorithms, to combine several assemblies into a single integrated assembly.
Earlier assembly algorithms developed for Sanger sequencing follow an 'overlap - layout - consensus' paradigm, where consensus refers to fixing errors in the contigs (Ewing and Green, 1998; Ewing et al., 1998).
Valoeuev et al. [ 8] have implemented an optical map assembler based on the overlap layout consensus (OLC) paradigm of sequence assembly.
Although this theory has been supported by accumulating evidence, it has only been collected from paradigms in which the entire spatial layout was simultaneously visible to observers.
The conventional Overlap Layout Consensus (OLC) strategy has been one of the most successful paradigms for assembling long Sanger-based reads.
The yFiles Organic layout (ORL) is a proprietary closed-source implementation of the force-directed placement paradigm, which combines elements from several layout algorithms to facilitate identification of clusters of tightly connected network modules [ 20], hence sharing the same objective with the MLL-C.
This layout, which Google popularized through its Google Now search application, has become the new go-to design paradigm at Google, arriving across other Google products and services, including Google Drive, the new Google Wallet apps, Maps, Google+ and elsewhere.
