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De Boer et al (1997) showed that expression of different NRG1 isoforms varied in different cell layers of the normal and malignant bladder.
MoAb 35.48 binds to all cell layers of the normal urothelium and well differentiated tumours, but not to the majority of poorly differentiated tumours.
The restriction of survivin expression to the basal layers of the normal oesophageal squamous cell epithelium suggests that survivin may be related to cell proliferation.
The VHR immunoreactivity was very low in the (para) basal cell layers of the normal squamous epithelium (Fig. 2A, panel a) whereas an intense staining was observed in H-SIL and SCC (Fig. 2A, panels c and d).
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Ultrastructural studies have indicated that the thin layer of neuronal processes surrounding the dark rosettes correspond to the outer plexiform layer, and the central region of the pale rosettes correspond to the inner plexiform layer of the normal retina.
The cellular composition of these structures indicated that the dark rosettes correspond to the outer nuclear layer and the pale rosettes to the inner nuclear layer of the normal retina.
Keratinocytes propagated in low calcium (30 microM CaCl2) serum-free media grow in a monolayer and exhibit morphologic and biosynthetic phenotypes most similar to those of keratinocytes in the basal layer of the normal epidermis.
Mitostatin was expressed mainly in the cytoplasm of the basal cell layer of the normal prostatic epithelium (Figure 7B) and a strong positivity was observed in the so called prostatic gland atrophy (Figure 7C).
In this study, we demonstrated that Brn2 mRNA and protein levels were increased in 14 days after calcium treatment of primary keratinocytes, consistent with its exclusive expression in the granular layer of the normal epidermis.
Our data accumulate into a hierarchical model of prostate renewal in which we define novel Clu+Tacstd2+Sca-1+ lineage-specific progenitor cells in the luminal epithelial layer of the normal prostate (Figure 7).
As shown in Figure 5a, p63-positive cells are detectable in the basal layer of the normal epidermis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com