By tweaking its coat protein, researchers could potentially adapt AAV to infect only ON bipolar cells, adding another layer of specificity.
Another player in the nanoparticle-delivery space, BIND Biosciences, adds a layer of specificity to its delivery by affixing targeting molecules to the outside of its nanoparticles (see "Fine-tuning Nanotech to Target Cancer").
Monitoring the functional status of proteins may therefore be highly germane to clinical applications, and offer an additional layer of specificity for enhancing our scientific understanding of causal progression of disease.
Does the expansion of ATG8 genes reflect another layer of specificity underlying bacterial autophagy?
Combinatorial regulation with additional signals, as seen in synapse formation in the Drosophila neuromuscular junction [ 4], might also provide an additional layer of specificity.
The study provided evidence that local sequence context provides an additional layer of specificity enhancement beyond the general sequence motifs uncovered by regular degenerate peptide library screens [ 20, 66].
Should it be the case that the LECA underwent multiple lifecycle stages, encoding multiple differentially expressed forms of Sec24 would have added another layer of specificity enabling tighter regulation of the coat complex, as well as provide additional regulatory mechanisms for the various cargoes to be exported.
"I look forward to taking the heart of 'Jagged Little Pill' and expanding its story, fleshing it out into ever deeper layers of emotionality, specificity, humanity, power, physicality, spirit and fabulism," explained Morissette in a press release for the musical.
SNAREs are sufficient to drive basal fusion of liposomes and impose a layer of compartmental specificity (Weber et al., 1998; McNew et al., 2000).
