Ozlem, S. & Akkaya, E. U. Thinking outside the silicon box: molecular AND logic as an additional layer of selectivity in singlet oxygen generation for photodynamic therapy.
Therefore, unlike inhibiting Plk1 KD, antagonizing the PBD function may allow one to uniquely impose an additional layer of selectivity in killing cancer cells, but not normal cells.
The docking motif then provides a crucial secondary layer of selectivity for the MAP kinase of interest.
The CSox module would provide fluorescent readout of kinase activity in addition to a first layer of selectivity for the MAP kinase of interest based on the SP/TP and extended phosphorylation consensus sequence.
Waters 'C' and 'D' likely provide an additional layer of selectivity through interactions with the unprotonated N1 amine on t1A, and may interact with the purine N2 amine, which does not directly contact Ago2.
By altering the gate material, depositing layers of selective membrane or a bio-recognition element onto the gate, variance of selectivity can be achieved [13, 14].
Verma, R., Oania, R., Graumann, J. & Deshaies, R. J. Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system.
It can be seen in Figure 1 that the selected non-water etchant based on amine solution is characterized by good selectivity for the annealed Ge25Se75 layer (the value of selectivity defined by the ratio of the dissolution rates for exposed and unexposed layers reached 20).
Significantly, the skillful regulation of interfacial polymerization by the control of deposition amount of eGO on nanofibrous substrate enabled the strong interfacial interaction and the formation of compact selective layer, determining the augment of selectivity of TFNC membranes.
