Second, layering mechanism, where new rules are attached to existing ones, is typically expected to destabilize existing institutions but can also decrease the push for broader change by layering regulation only for a particular segment.
The results identified tissue-specifically expressed, feedback-regulated, stress-responsive and alternatively spliced novel genes, revealed multiple layer regulation of GA metabolism, and provided evidence for crosstalk between GA metabolism and tanshinone biosynthesis in S. miltiorrhiza.
The results show tissue-specifically expressed, feedback-regulated, stress-responsive and alternatively spliced novel genes and reveal multiple layer regulation of GA metabolism and crosstalk between gibberellin metabolism and tanshinone biosynthesis in S. miltiorrhiza.
Taken together, our results reveal multiple layer regulation of GA metabolism and crosstalk between GA metabolism and tanshinone biosynthesis in S. miltiorrhiza.
This possible two-layer regulation mechanism by positive T-DMRs may be unique to development and the establishment of tissue-specific expression.
In the cancer study, genes whose expression is positively correlated with C-DMRs are not enriched for transcriptional repressors, suggesting that such a two-layer regulation mechanism is not an important feature in the development of cancer.
Multiple layer regulation may greatly help keeping GA content at the appropriate level and satisfying the needs of cells and organs at different developmental stages and under different environmental conditions.
We do not observe a two-layer regulation when we analysed the association of cancer-specific DMRs (C-DMRs) and gene expression differences between colon cancer and normal tissue (data not shown) [ 10].
Successive presidents have layered on regulations and loopholes, creating a form of state capitalism in which big businesses thrive because they have political connections and small businesses struggle.
In addition, it is reported by Kang et al. that there are two-layer regulations on the gene expression, where TFs function as important mediators of miRNA-initiated regulatory effects [ 33].
Comparative analysis of these two mechanism-based models suggests several intriguing testable predictions that can help understand this multi-layered regulation of EMT/MET.
