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Cosmoid scales have a hard, enamel-like outer layer, an inner layer of cosmine (a form of dentine), and then a layer of vascular bone (isopedine).
We hypothesize that the high spatial organization of the medial layer of vascular smooth muscle cells (VSMCs) and their surrounding matrix provides high burst strength, compliance, and stability.
Meanwhile, the layer of vascular bundle sheath cells in the Wuyunjing23 cultivar rapidly decreased under higher N rates (Fig. 3b).
Skin biopsies were taken from 14/24 CADASIL patients to further confirm the diagnosis of CADASIL, and GOM accumulation was detected in the basal layer of vascular smooth muscle cells in 6/14 patients (Fig. 2).
In the wt recipients neointima was almost exclusively formed by a thin layer of vascular SMC (Supplemental Fig. 1G).
FN was usually found in the inner layer of vascular walls in normal and pathological lungs, indicating uniformity throughout the lung (Additional file 2).
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Furthermore, depth information is available and allows for assessment and segmentation of different layers of vascular beds.
These lesions consisted of mesothelial hyperplasia on the surface of plump and non-cohesive mesothelial cells and in the underlying layers of vascular and fibroblastic granulation tissue.
Cultured decidual biopsy paraffin embedded sections were immunostained for H-caldesmon and the number of layers of vascular smooth muscle cells surrounding the vessel assessed.
Light microscopy and transmission electron microscopy examination showed there were layers of vascular smooth muscle cells and endothelial cells adhered in the inner wall of artificial blood vessel without any signs of thrombosis.
The absence of arterial calcifications in zebrafish embryos can probably be attributed to the morphological differences in the arteries of zebrafish embryos when compared with the medium and large arteries of human and mouse, which have multiple layers of vascular smooth muscle cells.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com