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Interestingly, miR-34a targets cyclin E2, cyclin D1, CDK4, CDK6 and E2F3, providing a second layer of repression of the cell-cycle machinery [ 56, 66, 90].
It implies that during typical development, active transcription of these microRNAs is combined with synergistic target methylation to create a double layer of repression of these target genes; a repression that is lifted in association with child abuse.
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He also admitted to being a romantic guy, though it's buried under "layers and layers" of "repression and ham".
Hoover had attempted suicide after being jilted by a gay lover; while he had marginally more relationship experience than Stitzer, the layers of repression and depression surrounding his love history were more or less imported wholesale, and easily portable.
In WT ESCs, the high expression of pluripotency factors is another layer of Xist repression.
How various layers of epigenetic repression restrict somatic cell nuclear reprogramming is poorly understood.
This in turn suggests that other layers of transcriptional repression might be involved in the silencing of P. falciparum genes.
The proceedings here seem riddled with the anxieties of proud parents and nervous new couples, fraught with various forms of repression, layered with punctiliously observed social decorum and coated with a penchant for ostentatious display.
RBP-J is essential for mediating both induction of spinous layer genes and repression of basal genes.
As centuries' worth of grimy layers on an immortal marble body dissolve, so do the layers of denial and repression that have long inhibited the people working on his makeover.
But poking the bear of repression has consequences beyond Mr. Zahedi's immediate artistic goals, as this layered, intermittently fascinating documentary makes abundantly clear.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com